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National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, 1(125), p. 104-110, 2017

DOI: 10.1289/ehp36

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Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO <sub>2</sub> Air Pollution Exposure

Journal article published in 2017 by Olena Gruzieva, Cheng-Jian Xu, Carrie V. Breton, Isabella Annesi-Maesano, Josep M. Antó, Charles Auffray, Stéphane Ballereau, Tom Bellander, Jean Bousquet, Mariona Bustamante ORCID, Marie-Aline Charles, Yvonne de Kluizenaar, Herman T. den Dekker, Liesbeth Duijts, Janine F. Felix and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239). RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p