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Lippincott, Williams & Wilkins, Therapeutic Drug Monitoring, 4(38), p. 487-492, 2016

DOI: 10.1097/ftd.0000000000000307

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SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

Journal article published in 2016 by Maja Matic, Saskia N. de Wildt ORCID, Laure Elens ORCID, Jan N. de Hoon, Pieter Annaert, Dick Tibboel, Ron H. N. van Schaik, Karel Allegaert
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This study determined whether SLC22A1 (encoding the organic cation transporter 1 (OCT1)) genotype could explain, in addition to postmenstrual age (PMA) (referring to gestational plus postnatal age) and CYP2D6 genotype, the tramadol (M) pharmacokinetic variability in early infancy.