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International Union Against Tuberculosis and Lung Disease, International Journal of Tuberculosis and Lung Disease, 3(19), p. 339-341

DOI: 10.5588/ijtld.14.0814

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Concordance of Mycobacterium tuberculosis Fluoroquinolone Resistance testing: implications for treatment

Journal article published in 2015 by Maha R. Farhat ORCID, Carole D. Mitnick, Molly F. Franke, Devinder Kaur, Alex Sloutsky, Megan Murray, Karen R. Jacobson
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Fluoroquinolone susceptibility-testing is an important step in the design of effective treatment regimens for multidrug-resistant tuberculosis. Here we compare ciprofloxacin, ofloxacin and moxifloxacin resistance results from 226 multidrug-resistant samples. The low level of concordance observed supports that drug sensitivity tests should be performed for the specific FLQ planned for clinical use. The results also support the new WHO recommendation for testing moxifloxacin at a critical-concentration of 2.0μg/ml.