Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Mahajan, Anubha; Ärnl, Johan; Rodan, Aylin R.; Le, Thu H.; Gaulton, Kyle J.; Haessler, Jeffrey; Stilp, Adrienne M.; Kamatani, Yoichiro; Zhu, Gu; Sofer, Tamar; Puri, Sanjana; Schellinger, Jeffrey N.; Chu, Pei-Lun; Cechova, Sylvia; van Zuydam, Natalie; Arnlov, Johan; Flessner, Michael F.; Giedraitis, Vilmantas; Heath, Andrew C.; Kubo, Michiaki; Larsson, Anders; Lindgren, Cecilia M.; Madden, Pamela A. F.; Montgomery, Grant W.; Papanicolaou, George J.; Reiner, Alex P.; Sundström, Johan; Thornton, Timothy A.; Lind, Lars; Ingelsson, Erik; Cai, Jianwen; Martin, Nicholas G.; Kooperberg, Charles; Matsuda, Koichi; Whitfield, John B.; Okada, Yukinori; Laurie, Cathy C.; Morris, Andrew P.; Franceschini, Nora

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Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Journal article published in 2016 by Anubha Mahajan, Johan Ärnl, Aylin R. Rodan, Thu H. Le, Kyle J. Gaulton, Jeffrey Haessler, Adrienne M. Stilp, Yoichiro Kamatani, Gu Zhu, Tamar Sofer, Sanjana Puri, Jeffrey N. Schellinger, Pei-Lun Chu, Sylvia Cechova, Natalie van Zuydam and other authors.

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Abstract

We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p