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BioMed Central, BMC Genomics, 1(15), 2014

DOI: 10.1186/1471-2164-15-943

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Comparative genomics of the major fungal agents of human and animal Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis

Journal article published in 2014 by Marcus M. Teixeira, Luiz Gp de Almeida ORCID, Paula Kubitschek-Barreira, Fernanda L. Alves, Érika S. Kioshima, Ana Kr Abadio, Larissa Fernandes, Lorena S. Derengowski, Karen S. Ferreira, Rangel C. Souza, Jeronimo C. Ruiz, Nathalia C. de Andrade, Hugo C. Paes, André M. Nicola, Patrícia Albuquerque and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliensis; 2) to compare S. brasiliensis, which is cat-transmitted and infects both humans and cats with S. schenckii, mainly a human pathogen; 3) to compare these two species to other human pathogens (Onygenales) with similar thermo-dimorphic behavior and to other plant-associated Sordariomycetes.