Published in

Springer (part of Springer Nature), Journal of Biomolecular NMR, 3(66), p. 187-194

DOI: 10.1007/s10858-016-0066-5

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High Sensitivity High-Resolution Full Range Relaxometry Using a Fast Mechanical Sample Shuttling Device and a Cryo-probe

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Field-dependent NMR studies of bio-molecular systems using a sample shuttling hardware operating on a high-field NMR apparatus have provided valuable structural and dynamic information. We have recently published a design of a compact sample transportation device, called ‘‘field-cycler’’, which was installed in a commercial spectrometer and which provided highly precise positioning and stability during high speed shuttling. In this communication, we demonstrate the first use of a sample shuttling device on a commercial high field standard bore NMR spectrometer, equipped with a commercial triple resonance cryogenically cooled NMR probe. The performance and robustness of the hardware operating in 1D and 2D field cycling experiments, as well as the impact of the sample shuttling time on the signal intensity are discussed.