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Frontiers Media, Frontiers in Microbiology, (7), 2016

DOI: 10.3389/fmicb.2016.00313

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Cytosolic Innate Immune Sensing and Signaling upon Infection

Journal article published in 2016 by Lilliana Radoshevich ORCID, Olivier Dussurget ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.