Published in

Nature Research, Nature Medicine, 10(17), p. 1199-1199, 2011

DOI: 10.1038/nm.2523

Nature Research, Nature Genetics, 10(43), p. 969-976

DOI: 10.1038/ng.940

Links

Tools

Export citation

Search in Google Scholar

Genome-wide association study identifies five new schizophrenia loci

Journal article published in 2011 by Stan Zammitt, M. de Hert, Stephan Ripke, E. van Den Oord, Alan R. Sanders, Kenneth S. Kendler, Durk Wiesrma, Douglas F. Levinson, Lieuwe de Haan, Pamela Sklar, Byerley Wf, Peter A. Holmans, Carr Vj, Dan-Yu Lin, Lasseter Vk and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding ( P = 1.6 × 10 − 11 ) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137 , suggesting MIR137 -mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10 − 9 ), ANK3 (rs10994359, P = 2.5 × 10 − 8 ) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10 − 9 ). ; PUBLISHED ; We thank the study participants and the research staff at the many study sites. Over 40 US National Institutes of Health grants and similar numbers of government grants from other countries, along with substantial private and foundation support, enabled this work. We greatly appreciate the sustained efforts of T. Lehner (National Institute of Mental Health) on behalf of the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC).