Published in

EMBO Press, EMBO Reports, 4(14), p. 356-363, 2013

DOI: 10.1038/embor.2013.16

Links

Tools

Export citation

Search in Google Scholar

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

Journal article published in 2013 by Irmina Diala, Nicole Wagner ORCID, Frédérique Magdinier, Marina Shkreli, Maria Sirakov, Serge Bauwens, Caroline Schluth-Bolard, Thomas Simonet, Valérie M. Renault, Jing Ye, Abdelnnadir Djerbi, Pascal Pineau, Jinkuk Choi, Steven Artandi, Anne Dejean and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/β-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, β-catenin binds to TRF2 gene regulatory regions that are functional in a luciferase transactivating assay. Reduced β-catenin expression in cancer cells triggers a marked increase in telomere dysfunction, which can be reversed by TRF2 overexpression. We conclude that the Wnt/β-catenin signalling pathway maintains a level of TRF2 critical for telomere protection. This is expected to have an important role during development, adult stem cell function and oncogenesis.