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Wiley, FEBS Letters, 8(579), p. 1821-1827

DOI: 10.1016/j.febslet.2005.02.001

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From protein networks to biological systems.

Journal article published in 2005 by Peter Uetz ORCID, Russell L. Finley
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A system-level understanding of any biological process requires a map of the relationships among the various molecules involved. Technologies to detect and predict protein interactions have begun to produce very large maps of protein interactions, some including most of an organism's proteins. These maps can be used to study how proteins work together to form molecular machines and regulatory pathways. They also provide a framework for constructing predictive models of how information and energy flow through biological networks. In many respects, protein interaction maps are an entrée into systems biology.