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Springer, Journal of Autism and Developmental Disorders, 2(39), p. 210-211, 2008

DOI: 10.1007/s10803-008-0640-0

Springer Verlag, Journal of Autism and Developmental Disorders, 2(39), p. 197-209

DOI: 10.1007/s10803-008-0621-3

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Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders

Journal article published in 2008 by Myra O'Regan, Aisling Mulligan, Richard J. L. Anney, Myra O’Regan, Wai Chen, Louise Butler, Michael Fitzgerald, Jan K. Buitelaar, Hans-Christoph Steinhausen, Aribert Rothenberger, Ruud B. Minderaa, Judith S. Nijmeijer, Peter J. Hoekstra, Robert D. Oades, Herbert Roeyers and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.