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EMBO Press, EMBO Reports, 12(14), p. 1113-1119, 2013

DOI: 10.1038/embor.2013.165

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Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response

Journal article published in 2013 by Antje Krüger, Jakob Vowinckel, Michael Mülleder, Phillip Grote, Floriana Capuano, Katharina Bluemlein, Markus Ralser ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cells counteract oxidative stress by altering metabolism, cell cycle and gene expression. However, the mechanisms that coordinate these adaptations are only marginally understood. Here we provide evidence that timing of these responses in yeast requires export of the polyamines spermidine and spermine. We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1-controlled polyamine export.