Published in

Elsevier, Schizophrenia Research, 2-3(159), p. 329-332, 2014

DOI: 10.1016/j.schres.2014.08.007

Links

Tools

Export citation

Search in Google Scholar

No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure

Journal article published in 2014 by Helena Cousijn ORCID, Marc Eissing, Guillén S. E. Fernández, Simon E. Fisher ORCID, Barbara Franke ORCID, Marcel Zwiers, Paul J. Harrison, Alejandro Arias-Vásquez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects—including the combined effect of the genes—nor single SNP effects—including specific psychosis risk SNPs—were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.