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Royal Society of Chemistry, MedChemComm, 2(6), p. 357-362

DOI: 10.1039/c4md00454j

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Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Journal article published in 2015 by Margherita Brindisi, Sandra Gemma ORCID, Sanil Kunjir, Luisa Di Cerbo, Simone Brogi, Silvia Parapini, Sarah D'Alessandro, Donatella Taramelli, Annette Habluetzel, Sofia Tapanelli, Stefania Lamponi, Ettore Novellino, Giuseppe Campiani, Stefania Butini ORCID
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This paper is available in a repository.

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Abstract

Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo