Published in
American Society of Hematology, Blood, 1(127), p. 91-101, 2016
DOI: 10.1182/blood-2015-06-649145
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Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
Journal article published in 2015 by
Eveline M. Delemarre,
Theo van den Broek 
,
Gerdien Mijnheer,
Jenny Meerding,
Ellen J. Wehrens,
Sven Olek,
Marianne Boes,
Martijn J. C. van Herwijnen,
Femke Broere,
Annet van Royen,
Nico M. Wulffraat,
Berent J. Prakken,
Eric Spierings,
Femke van Wijk
,
Gerdien Mijnheer,
Jenny Meerding,
Ellen J. Wehrens,
Sven Olek,
Marianne Boes,
Martijn J. C. van Herwijnen,
Femke Broere,
Annet van Royen,
Nico M. Wulffraat,
Berent J. Prakken,
Eric Spierings,
Femke van Wijk
This paper is made freely available by the publisher.
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Abstract
Key Points Autologous HSCT induces functional renewal of regulatory T cells as well as a strong Treg TCR diversification in autoimmune patients. Adding regulatory T cells to the graft does not lead to additional clinical improvement but results in delayed donor T-cell reconstitution.