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Facultad de Humanidades y Ciencias de la Educación, Synthesis: Journal of Synthetic Organic Chemistry, 01(48), p. 79-84

DOI: 10.1055/s-0035-1560833

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N-Heterocyclic Carbene-Catalyzed Vinylogous Mukaiyama Aldol Reaction of α-Keto Esters and α-Trifluoromethyl Ketones

Journal article published in 2015 by Guang-Fen Du, Ying Wang, Fen Xing, Mei Xue, Xu-Hong Guo, Kuo-Wei Huang ORCID, Bin Dai
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

© Georg Thieme Verlag Stuttgart · New York · Synthesis 2016. N-Heterocyclic carbene (NHC)-catalyzed vinylogous Mukaiyama aldol reaction of ketones was developed. Under the catalysis of 5 mol% NHC, α-keto esters and α-trifluoromethyl ketones reacted with 2-(trimethysilyloxy)furan efficiently to produce γ-substituted butenolides containing adjacent quaternary and tertiary carbon centers in high yields with good diastereoselectivities.