Published in
Springer, Acta Neuropathologica, 4(123), p. 485-499, 2012
DOI: 10.1007/s00401-012-0959-7
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- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Subgroup Specific Alternative Splicing in Medulloblastoma
Journal article published in 2012 by
Adrian M. Dubuc,
A. Sorana Morrissy,
Nanne K. Kloosterhof,
Paul A. Northcott 
,
Emily Py Y. Yu,
David Shih,
John Peacock,
Wieslawa Grajkowska,
Timothy van Meter,
Charles G. Eberhart,
Stefan Pfister,
Marco A. Marra,
William A. Weiss,
Stephen W. Scherer,
James T. Rutka
and other authors.
,
Emily Py Y. Yu,
David Shih,
John Peacock,
Wieslawa Grajkowska,
Timothy van Meter,
Charles G. Eberhart,
Stefan Pfister,
Marco A. Marra,
William A. Weiss,
Stephen W. Scherer,
James T. Rutka
and other authors.
This paper is made freely available by the publisher.
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Abstract
Medulloblastoma is comprised of four distinct molecular variants: WNT, SHH, Group 3, and Group 4. We analyzed alternative splicing usage in 14 normal cerebellar samples and 103 medulloblastomas of known subgroup. Medulloblastoma samples have a statistically significant increase in alternative splicing as compared to normal fetal cerebella (2.3-times; P