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Cold Spring Harbor Perspectives in Biology, 2(2), p. a000166-a000166

DOI: 10.1101/cshperspect.a000166

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Ubiquitination and Degradation of the Inhibitors of NF- B

Journal article published in 2009 by N. Kanarek, N. London, O. Schueler-Furman ORCID, Y. Ben-Neriah
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.