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Elsevier, Molecular and Cellular Proteomics, 5(14), p. 1400-1410, 2015

DOI: 10.1074/mcp.m114.044305

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Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues*

Journal article published in 2015 by Roland Bruderer, Oliver M. Bernhardt, Tejas Gandhi, Saša M. Miladinović, Lin-Yang Cheng, Simon Messner, Tobias Ehrenberger, Vito Zanotelli ORCID, Yulia Butscheid, Claudia Escher, Olga Vitek, Oliver Rinner, Lukas Reiter
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The data-independent acquisition (DIA) approach has recently been introduced as a novel mass spectrometric method that promises to combine the high content aspect of shotgun proteomics with the reproducibility and precision of selected reaction monitoring. Here, we evaluate, whether SWATH-MS type DIA effectively translates into a better protein profiling as compared with the established shotgun proteomics.