Wireless technologies have lately been integrated in many types of environments; their development is able to provide innovative services minimizing costs and the time necessary to identify the necessary information. However medical information is very sensitive since it contains critical personal data. Security and privacy preservation are very critical parameters. Lately, innovative technologies such as software agents’ technology have been utilized to support distributed environments. Presented is an architecture that allows secure medical related information management using software agents; this work expands previous research (Belsis, Skourlas, & Gritzalis, 2011). The authors present a security oriented solution and also provide experimental evidence about the capability of the platform to operate in wireless environments with large number of users.