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Cold Spring Harbor Perspectives in Medicine, 9(3), p. a010298-a010298

DOI: 10.1101/cshperspect.a010298

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RNA-Mediated Regulation in Pathogenic Bacteria

Journal article published in 2013 by Isabelle Caldelari, Yanjie Chao, Pascale Romby, Jörg Vogel ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors, and enable the bacteria to survive and proliferate after host infection. Regulatory RNAs are now recognized as important components of these networks, and their study may not only identify new approaches to combat infectious diseases but also reveal new general control mechanisms involved in bacterial gene expression. In this review, we illustrate the diversity of regulatory RNAs in bacterial pathogens, their mechanism of action, and how they can be integrated into the regulatory circuits that govern virulence-factor production.