Published in
Elsevier, Biological Psychiatry, 7(64), p. 571-576
DOI: 10.1016/j.biopsych.2008.02.024
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Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings
,
Jan K. Buitelaar,
Richard Ebstein,
Rjl J. L. Anney,
Michael Gill,
I. Gabris,
Keeley Brookes,
Cathelijne Buschgens,
Desmond Campbell ,
Wai Chen,
Hanna Christiansen,
Ellen Fliers
and other authors.
Full text: Download
Abstract
BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p