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Royal Society of Chemistry, Chemical Communications, 40(50), p. 5261-5263

DOI: 10.1039/c3cc47534d

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Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B-N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.