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Cell Press, Cell Metabolism, 3(15), p. 279-291, 2012

DOI: 10.1016/j.cmet.2011.12.018

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FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

Journal article published in 2012 by Rudolf Zechner ORCID, Robert Zimmermann ORCID, Thomas O. Eichmann ORCID, Sepp D. Kohlwein, Guenter Haemmerle, Achim Lass ORCID, Frank Madeo
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Abstract

Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism. New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.