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Elsevier, Gene, 1(576), p. 292-303, 2016

DOI: 10.1016/j.gene.2015.10.039

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Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells

Journal article published in 2016 by Ling Ling, Emily T. Camilleri ORCID, Torben Helledie, Rebekah M. Samsonraj ORCID, Drew M. Titmarsh, Ren Jie Chua, Oliver Dreesen, Christian Dombrowski, David A. Rider, Mario Galindo, Ian Lee, Wanjin Hong, James H. Hui, Victor Nurcombe, Andre J. van Wijnen and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism invokes many adverse systemic events including thrombocytopenia, vascular reactions and osteoporosis. Here, we addressed whether adverse effects might also be directed to mesenchymal stem cells that reside in the bone marrow compartment. Harvested human bone marrow-derived mesenchymal stem cells (hMSCs) were exposed to varying doses of heparin and their responses profiled. At low doses (