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PeerJ, PeerJ, (2), p. e315

DOI: 10.7717/peerj.315

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DoReMi: context-based prioritization of linear motif matches

Journal article published in 2014 by Heiko Horn, Niall Haslam, Lars Juhl Jensen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Many protein domains bind to short peptide sequences, called linear motifs. Data on their sequence specificities is sparse, which is why biologists usually resort to basic pattern searches to identify new putative binding sites for experimental follow-up. Most motifs have poor specificity and prioritization of the matches is thus crucial when scanning a full proteome with a pattern.