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Nature Research, Nature Genetics, 6(39), p. 730-732, 2007

DOI: 10.1038/ng2047

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Tissue-Specific Transcriptional Regulation has Diverged Significantly between Human and Mouse

Journal article published in 2007 by Duncan T. Odom ORCID, Robin D. Dowell ORCID, Elizabeth S. Jacobsen, William Gordon, Timothy W. Danford, Kenzie D. MacIsaac, P. Alexander Rolfe, Caitlin M. Conboy, David K. Gifford, Ernest Fraenkel ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A, HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events appear to be species-specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.