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Royal Society of Chemistry, New Journal of Chemistry

DOI: 10.1039/c5nj02741a

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RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

Journal article published in 2015 by Sara Rojas, Carmen R. Maldonado, Francisco Jesus Carmona, Elisa Barea, Jorge A. R. Navarro ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

[Fe3F(H2O)2O(btc)2]·nH2O (H3btc: benzene-1,3,5-tricarboxylic acid) (MIL-100(Fe)) in the form of nanoparticles with average size of 135 ± 70 nm can be used for the adsorption and controlled delivery of metallodrug [Ru(p-cymene)Cl2(pta)] (RAPTA-C) in simulated body fluid (SBF). The results show that the RAPTA-C delivery process takes place in two steps exhibiting half-life times of 1.9 and 30 h. We also found a positive effect of bovine serum albumine (BSA) in speeding up the RAPTA-C delivery rate, which agrees with the suitability of MIL-100(Fe) as a drug delivery system (DDS) for the controlled release of RAPTA-C.