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Wiley, Angewandte Chemie, 8(128), p. 2906-2910, 2016

DOI: 10.1002/ange.201510808

Wiley, Angewandte Chemie International Edition, 8(55), p. 2856-2860

DOI: 10.1002/anie.201510808

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Enantioselective C−H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution

Journal article published in 2016 by Kai-Jiong Xiao ORCID, Ling Chu, Jin-Quan Yu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significant progress has been made in the past decade regarding the development of enantioselective C−H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C−H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C−H activation and C−C bond formation, thus significantly expanding the scope of enantioselective C−H activation reactions.