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Royal Society of Chemistry, Dalton Transactions, 8(44), p. 3540-3543

DOI: 10.1039/c4dt02663b

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Unprecedented dinuclear silver( i )-mediated base pair involving the DNA lesion 1,N 6 -ethenoadenine

Journal article published in 2015 by Soham Mandal, Alexander Hepp, Jens Müller ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The DNA lesion 1,N6-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA:εA mispair readily forms doubly silver(I)-mediated base pairs εA–Ag(I)2–εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.