There is a strong emphasis on developing novel neuroscience technologies, in particular on recording from more neurons. There has thus been increasing discussion about how to analyze the resulting big datasets. What has received less attention is that over the last thirty years, papers in neuroscience have progressively integrated more approaches, such as electrophysiology, anatomy, and genetics. As such, there has been little discussion on how to combine and analyze this multimodal data. Here, we describe the growth of multimodal approaches, and discuss the needed analysis advancements to make sense of this data.