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Oxford University Press (OUP), Nephrology Dialysis Transplantation, 10(26), p. 3286-3295

DOI: 10.1093/ndt/gfr323

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Epidemiology and prognostic significance of chronic kidney disease in the elderly--the Three-City prospective cohort study

Journal article published in 2011 by Bénédicte Stengel ORCID, Marie Metzger, Marc Froissart, Muriel Rainfray, Claudine Berr, Christophe Tzourio ORCID, Catherine Helmer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: Little is known about normal kidney function level and the prognostic significance of low estimated glomerular filtration rate (eGFR) in the elderly. METHODS: We determined age and sex distribution of eGFR with both the Modification of Diet in Renal Disease (MDRD) study and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in 8705 community-dwelling elderly aged ≥ 65 years and studied its relation to 6-year mortality. In a subsample of 1298 subjects examined at 4 years, we assessed annual eGFR decline and clinically relevant markers including microalbuminuria (3-30 mg/mmol creatinine) with diabetes, proteinuria ≥ 50 mg/mmol, haemoglobin