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Investigations in Yeast Functional Genomics and Molecular Biology, p. 283-310

DOI: 10.1201/b16586-16

BioMed Central, BMC Genomics, 1(14), p. 69

DOI: 10.1186/1471-2164-14-69

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High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome

Journal article published in 2013 by Gianni Liti, Alex N. Nguyen Ba, Alex N. Nguyen, Martin Blythe, Carolin A. Müller, Anders Bergström, Francisco A. Cubillos, Felix Dafhnis-Calas, Shima Khoshraftar, Sunir Malla, Neel Mehta, Cheuk C. Siow ORCID, Jonas Warringer, Alan M. Moses, Edward John Louis ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Comparative genomics is a formidable tool to identify functional elements throughout a genome. In the past ten years, studies in the budding yeast Saccharomyces cerevisiae and a set of closely related species have been instrumental in showing the benefit of analyzing patterns of sequence conservation. Increasing the number of closely related genome sequences makes the comparative genomics approach more powerful and accurate. Results Here, we report the genome sequence and analysis of Saccharomyces arboricolus , a yeast species recently isolated in China, that is closely related to S. cerevisiae . We obtained high quality de novo sequence and assemblies using a combination of next generation sequencing technologies, established the phylogenetic position of this species and considered its phenotypic profile under multiple environmental conditions in the light of its gene content and phylogeny. Conclusions We suggest that the genome of S. arboricolus will be useful in future comparative genomics analysis of the Saccharomyces sensu stricto yeasts.