Many genes expressed in the central nervous system are candidates for the susceptibility to suicidal behavior (SB) including serotonergic, noradrenergic, and dopaminergic systems [1 – 3]. We studied the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) system that plays a critical role in neuronal survival and morphogenesis and in brain plasticity. We ruled out the association between polymorphisms G196A and-281 C/A of the BDNF gene and suicide [4]. Thus, we demonstrated a decreased BDNF expression in Wernicke area of brain of suicide subjects, due to BDNF promoter hypermethylation [5] revealing, for the first time, an association between epigenetics and suicide. Furthermore, we investigated the other component of the system, i.e., the neurotrophic tyros-ine receptor kinase (NTRK) 2 gene, that encodes the TrkB receptor, excluding correlations between NTRK2 gene methylation in Wernicke area and suicide [6]. In addition, we evaluated NTRK2 expression of the main TrkB isoforms on Wernicke ' s area, i.e., Brodmann ' s area 22, that have relevant function in understanding and language [5]. Finally, we demonstrated that some NTRK2 polymorphisms pre-dispose to SB modulating the expression of the different isoforms of the receptor in Wernicke area [7]. All studies performed so far focused on point mutations in candidate genes. Recently, array-comparative genomic hybridization (a-CGH) has allowed the identification of gains and losses of DNA as small as few kilobases enabling a large number of genomic alterations associated with neurological disorders to be identified [8]. However, at present, no studies have been performed to identify genomic alterations in subjects with SB; in order to identify alterations that could be correlated to SB we analyzed by a-CGH DNA samples of brain tissue extracted postmortem from the Wernicke area obtained from 34 suicides (23 females and 11 males) and 34 non-suicide control subjects (21 females and 13 males), aged 17 – 30 years. The Wernicke ' s brain tissue samples were collected in the course of autopsy (Institute of Forensic Medicine, University of Ljubljana) and frozen at – 80 ° C within 26 h from the subject ' s death (Biological Bank of the Institut za Varovanje Zdravja, Ljubljana, Slovenia) between 1999 and 2005. The study was performed according to ethical issues of such institution and Helsinki Declaration as revised in 2008 and permission to use the samples was obtained by the institution that