Published in
American Society of Hematology, Blood, 2(126), p. 167-175, 2015
DOI: 10.1182/blood-2014-12-615898
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Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis
Journal article published in 2015 by
Stanley C. W. Lee 
,
Sarah Miller,
Craig Hyland,
Maria Kauppi,
Marion Lebois,
Ladina Di Rago,
Donald Metcalf,
Sarah A. Kinkel,
Emma C. Josefsson,
Marnie E. Blewitt,
Ian J. Majewski ,
Warren S. Alexander
,
Sarah Miller,
Craig Hyland,
Maria Kauppi,
Marion Lebois,
Ladina Di Rago,
Donald Metcalf,
Sarah A. Kinkel,
Emma C. Josefsson,
Marnie E. Blewitt,
Ian J. Majewski ,
Warren S. Alexander
This paper is made freely available by the publisher.
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Abstract
Key PointsInactivation of Suz12 results in a rapid and marked exhaustion of the HSC pool. Lymphoid development is completely dependent on PRC2, but numerous myeloid lineages develop in the absence of PRC2.