Researchers have searched for factors that predict the metastatic potential of melanomas for decades. In recent years, the study of their metastatic potential has progressed from routine histological analysis of Hematoxylin-Eosin stained slides to proteomic, genetic, and molecular pathological analyses. As a result, knowledge about the metastatic potential of melanomas has progressed. Hundreds of prognostic factors have been described in literature and it is not possible to mention all of them in a report. Therefore, in the current report, we summarize some of them.