Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA
Journal article published in 2008 by
Frédéric Rosu,
Valérie Gabelica 
,
Edwin De Pauw,
Patrick Mailliet,
Jean-Louis Mergny
,
Edwin De Pauw,
Patrick Mailliet,
Jean-Louis Mergny
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
DNA–drug dimers: Drugs based on the phenothiazine scaffold have a wide variety of therapeutic applications and are also used as DNA photosensitizers. Highly cooperative formation of a 2:1 complex was revealed by electrospray mass spectrometry experiments, and a structural model is proposed. This bisphenothiazine scaffold can therefore be exploited for future design of new minor groove binding agents having photosensitizing properties.