Published in
Royal Society of Chemistry, Chemical Communications, 34(46), p. 6314
DOI: 10.1039/c0cc00929f
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Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541
Journal article published in 2010 by
Martin Karabec,
Andrzej Łyskowski,
Katharina C. Tauber,
Georg Steinkellner,
Wolfgang Kroutil 
,
Gideon Grogan,
Karl Gruber
,
Gideon Grogan,
Karl Gruber
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Abstract
The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.