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Wiley, Angewandte Chemie International Edition, 8(45), p. 1267-1269, 2006

DOI: 10.1002/anie.200502599

Wiley, Angewandte Chemie, 8(118), p. 1289-1291, 2006

DOI: 10.1002/ange.200502599

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Structural Investigation of Cisplatin–Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase

Journal article published in 2006 by Vito Calderone, Angela Casini, Stefano Mangani, Luigi Messori ORCID, Pier Luigi Orioli
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This paper is available in a repository.

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Abstract

Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented)