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Springer Verlag, Lecture Notes in Computer Science, p. 49-60

DOI: 10.1007/978-3-642-31927-3_5

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RNA Folding Algorithms with G-Quadruplexes

Journal article published in 2012 by Ronny Lorenz ORCID, Stephan H. Bernhart, Fabian Externbrink, Jing Qin, Christian Höner zu Siederdissen, Fabian Amman, Ivo L. Hofacker, Peter F. Stadler ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

G-quadruplexes are abundant locally stable structural elements in nucleic acids. The combinatorial theory of RNA structures and the dynamic programming algorithms for RNA secondary structure prediction are extended here to incorporate G-quadruplexes using a simple but plausible energy model. With preliminary energy parameters we find that the overwhelming majority of putative quadruplex-forming sequences in the human genome are likely to fold into canonical secondary structures instead.