Air samples were collected concurrently at 05:00 a.m. and 10:00 a.m. local Beijing time (GMT + 8) at 84 sites during two grid-study campaigns on September 29th, 2008 and March 1st, 2009 in the Pearl River Delta region, in order to offer snapshots of ambient CFCs and HCFCs in different seasons and to indicate the presence of local emission sources. Compared to the subtropical northern hemisphere (NH) background levels, mean mixing ratios of CFC-11, CFC-12, CFC-113, CFC-114 and HCFC-22 were enhanced by 7% - 11%, 8% - 11%, 5% - 6%, 8% - 9% and 71% - 135%, respectively. When data from this study were pooled together with previous observations in the region, ambient CFC-11, CFC-12, and CFC-113 unambiguously showed declines in mixing ratios while HCFC-22 showed an increase. Spatial variations revealed potential emission hotspots in the region, and levels of CFCs and HCFC-22 were higher in September than in March due to many more refrigeration and air-conditioning activities during summer. Source apportioning by positive matrix factorization (PMF) revealed that new input of CFCs and HCFC-22 into the ambient air was largely attributed to emission from air-conditioning and refrigerating activities instead of industry activities. Average emissions in the region estimated by the CO-tracer method were 0.8 ± 0.2, 1.4 ± 0.6, 0.2 ± 0.1, 0.1 ± 0.02 and 4.4 ± 1.0 Gg/yr for CFC-11, CFC-12, CFC-113, CFC-114, and HCFC-22, respectively, and they accounted for 5.5% - 25.5% of total estimated CFC and HCFC-22 emissions in China.