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Elsevier, Journal of Inorganic Biochemistry, (155), p. 17-25, 2016

DOI: 10.1016/j.jinorgbio.2015.11.010

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Water soluble heterometallic potassium-dioxidovanadium(V) complexes as potential antiproliferative agents

Journal article published in 2015 by Manas Sutradhar ORCID, Alexandra R. Fernandes, Joana Silva, Kamran T. Mahmudov ORCID, Armando J. L. Pombeiro, M. Fátima C. Guedes da Silva ORCID
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This paper is available in a repository.

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Abstract

Two water soluble heterometallic potassium-dioxidovanadium polymers, [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2=(2,3-dihydroxybenzylidene) benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin.