Auditory effects of noise on humans have been established but aircraft noise has been associated with several health effects on non auditory system, as well. During the last decade the rise of low-cost airlines has increased air traffic thus exposing the population to increased noise levels and potential disturbances and health disorders. To estimate the exposure levels and evaluate the health impact of aircraft noise on residents nearby six airports in Italy (Rome: Ciampi no; Milan: Linate and Malpensa; Pisa; Turin; Venice) focusing on hypertension, acute myocardial infarction (AMI) , annoyance and sleep disturbances. Registry offices of the municipalities involved have provided residential addresses and personal data of all residents updated to 31/12/2010. Acoustic fingerprint of each airport to 2011 was estimated using the Integrated Noise Model. All residence addresses were geocoded and Lden (<55, 55-60, 60-65, 65-70 dB), Lnight, Leq (day and night) were assigned to each participant. Available exposure-response relationships were used to estimate the number of additional cases of hypertension, AMI, annoyance and sleep disturbances. 73,272 persons exposed to aircraft noise levels >55dB were considered: 55,915 (76.3%) were exposed to 55-60 dB; 16,562 (22.6%) to 60-65 dB; 795 (1.2%) to 65-70 dB. Exposure to aircraft noise levels above 55 dB was estimated to be responsible each year of 4,607 (95%CI 0-9,923) additional cases of hypertension; 3.4 (95%CI 0-10.7) cases of AMI; 9,789 (95%CI 6,895-11,962) cases of annoyance; 5,084 (95%CI 1,894-10,509) cases of sleep disturbances. A significant impact of airport noise on the health of residents nearby six Italian airports was estimated. Copyright© (2015) by EAA-NAG-ABAV, ISSN 2226-5147 All rights reserved 125