A numerical study is performed to simulate the vertical deformation of a depth interval representing a marker spacing ~10.5 m! located in a deep heterogeneous sedimentary reservoir. Realistic lithostratigraphic sequences typical of the Northern Adriatic basin are used. A number of scenarios are addressed consistent with the available data. In particular two basic geologic scenarios at the marker scale are simulated, one where sands prevail within the marker spacing ~SD!, and another where thin sandy and clayey layers alternate ~CL!. The sensitivity of the marker response is investigated in relation to clay and sand permeability and compressibility contrast, Biot's coefficient, and respective position of monitoring and fluid pumping wells. The modeling results show that rock may indeed expand above and below depleted layers. Depending on the marker position the expansion may partially offset the compaction, especially in the CL scenario with a very low permeable clay. To obtain a representative field compaction the markers should span a depth interval made mostly by sand and entirely depleted, and should be installed in a test hole far from producing wells. Compressibility contrast and the Biot coefficient play a secondary role. Very critical measurements are provided by two markers which incorporate a thin~' 1m ! depleted level overlain and underlain by almost impermeable clay layers.