The extensive volume change and continuous consuming of active electrode material due to the repeated formation of solid electrolyte interface (SEI) layer during charge-discharge cycles are two important topics to be concerned for the development of new nanostructured electrode in high-performance lithium ion batteries (LIBs). In this work, layer-stacked cobalt ferrite (CoFe2O4) mesoporous platelets with two different thicknesses are synthesized, and their electrochemical performance as anode of LIBs is evaluated. We find that the thickness of platelets has great impact on the specific capacity and stability. The thicker platelets (~2 µm) enable a reduction of SEI-induced consumption of active material and lead to an overall electrochemical performance superior to that of thinner ones. At a high rate of 5 A g-1, after an initial drop, the capacity of thicker platelets continuously increases in the following 500 cycles and reaches a saturation around 950 mAh g-1, then gradually decreases and maintains at 580 mAh g-1 after 2000 cycles. The high capacitance, outstanding rate performance and stability of thick platelets can be attributed to the special configuration of the layers-stacked mesoporous platelets which provides sufficient interlayer space for volume expansion, and enables the formation of a stable SEI layer during the cycling.