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Public Library of Science, PLoS ONE, 7(7), p. e40901, 2012

DOI: 10.1371/journal.pone.0040901

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Differential Trypanocidal Activity of Novel Macrolide Antibiotics; Correlation to Genetic Lineage

Journal article published in 2012 by Carolina Aquilino, Maria Luisa Gonzalez Rubio, Maria Luisa Gonzalez Rubio, Elena Maria Seco, María Elena Seco, Leticia Escudero, Laura Corvo, Manuel Soto ORCID, Manuel Fresno, Francisco Malpartida, Pedro Bonay
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Here we report the systematic study of the anti-trypanocidal activity of some new products derived from S. diastatus on 14 different T. cruzi strains spanning the six genetic lineages of T. cruzi. As the traditional growth inhibition curves giving similar IC(50) showed great differences on antibiotic and lineage tested, we decided to preserve the wealth of information derived from each inhibition curve and used an algorithm related to potency of the drugs, combined in a matrix data set used to generate a cluster tree. The cluster thus generated based just on drug susceptibility data closely resembles the phylogenies of the lineages derived from genetic data and provides a novel approach to correlate genetic data with phenotypes related to pathogenesis of Chagas disease. Furthermore we provide clues on the drugs mechanism of action.