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Oxford University Press, Human Molecular Genetics, 3(25), p. 620-629, 2016

DOI: 10.1093/hmg/ddv494

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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Journal article published in 2016 by Zhaoming Wang, Wei Jie Seow, Kouya Shiraishi, Chao A. Hsiung, Keitaro Matsuo ORCID, Kexin Chen ORCID, K. Chen, Taiki Yamji, Jie Liu, Yang Yang, I.-Shou Chang, Chen Wu ORCID, Yun-Chul Hong, Laurie Burdett, Kathleen Wyatt and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6,877 cases and 6,277 controls) using the 1,000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5,878 cases and 7,046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR)=1.17; P=5.8×10(-13)), rs72658409 at 9p21.3 (per-allele OR=0.77; P=1.41 ×10(-10)), and rs11610143 at 12q13.13 (per-allele OR=0.89; P=4.96 ×10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.