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MDPI, Biosensors, 1(6), p. 1, 2016

DOI: 10.3390/bios6010001

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Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection

Journal article published in 2016 by Tatevik Chalyan, Romain Guider, Laura Pasquardini ORCID, Manuela Zanetti, Floris Falke, Erik Schreuder, Rene G. Heideman, Cecilia Pederzolli, Lorenzo Pavesi ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si₃N₄ Asymmetric Mach-Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab'). We measured a best volumetric sensitivity of 10⁴ rad/RIU, leading to a Limit of Detection below 5 × 10(-7) RIU. On sensors functionalized with Fab', we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.