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Elsevier, Psychiatry Research, 3(225), p. 489-492

DOI: 10.1016/j.psychres.2014.11.061

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The role of the potassium channel gene KCNK2 in major depressive disorder

Journal article published in 2015 by Chiara Congiu, Minelli Alessandra, A. Minelli, Cristian Bonvicini ORCID, Marco Bortolomasi, Sartori Riccardo, R. Sartori, Maj C., Carlo Maj, Catia Scassellati ORCID, Giuseppe Maina ORCID, Luigi Trabucchi, Matilde Segala, Massimo Gennarelli
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This paper is available in a repository.

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Abstract

Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.