Nature Research, Nature Genetics, 11(43), p. 1047-1048, 2011
DOI: 10.1038/ng.984
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Diversification and specialization of high-throughput technologies demand assay-specific treatment of data for reliable interpretation. A new study shows that data generated using the Hi-C approach contain hidden features of interchromosomal DNA interactions, which are revealed through analysis with an integrated probabilistic model that corrects for multiple sources of bias in the data.